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Light Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1607 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/light+microscope/Leica+DM2500+Optical+Microscopes/pmc13695017-96-11-13
Average 96 stars, based on 1607 article reviews
Light Microscope, supplied by Danaher Inc, used in various techniques. Bioz Stars score: 96/100, based on 1607 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/light+microscope/Leica+DM2500+Optical+Microscopes/pmc13695017-96-11-13
Average 96 stars, based on 1607 article reviews
light microscope - by Bioz Stars,
2026-11
96/100 stars
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Light Microscopy:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a Analysis:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a Staining:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a H&E Stain:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a Safranin O Staining:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a Microscopy:Article Title: Potential Role of Zn Supplementation in Ameliorating Reserpine-Induced Fibromyalgia Manifestations Through Central NLRP3-Autophagy-Redox Network Modulation in Rats. Article Snippet: The slides were examined by an independent, blinded histologist under light microscope (Leica DM4 B, Leica Microsystems GmbH, Wetzlar, Germany), who chose random non-overlapping photomicrographs for each organ in each study group for analysis and Article Title: Apolipoprotein A1 attenuates epirubicin-induced cardiotoxicity with GPX4-linked ferroptosis-defense modulation. Article Snippet: 1 Department of Cardiovascular Medicine, Cardiovascular Research Center, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing 400016, China 2 Special Medical Service Centre, Department of Cardiovascular Medicine, The First Affiliated Hospital of Chongqing Medical University (Jingwei Campus), No. 24 Shiyou Road, Yuzhong District, Chongqing, China Abstract Anthracycline-induced cardiotoxicity (AIC), in which ferroptosis-related cardiomyocyte injury has been implicated, remains a major challenge in oncology.. This study investigates the therapeutic potential of an apolipoprotein A1 (ApoA1) mimetic peptide, L-4 F, in epirubicin-induced cardiotoxicity (EIC) in a rat model.. Rats received epirubicin (2.5 mg/ kg/week, i.p.) for six weeks to establish the EIC model, with or without concurrent ApoA1 mimetic treatment (L-4 F, 1 mg/kg/day). Article Title: Neurotensin modulation of immune and oxido-inflammatory homeostasis targeting TGF-β activated kinase 1/Nuclear factor-kappa βeta pathway: an integrated in vivo and in silico study. Article Snippet: 1 Deapartmet of Zoology, University of Allahabad, Allahabad, India Abstract Background Neurotensin (NTS) is a brain peptide and is known to regulate several brain pathways.. Subsequently NTS involvement in psychosis was administered having its promising therapeutic effects as an antipsychotic drug.. Therefore, it has been deduced that targeting the NTS system in the regulation of the immune organs would prove to be a productive strategy for developing the novel immune modulatory drugs. Article Title: Histone H3K4 Methylation Mediates Exogenous Arginine Suppression of Cold-Induced Damage in Tea Plant. Article Snippet: Cold stress severely restricts the geographical distribution and productivity of Camellia sinensis (tea plant).. Although the plant cuticle wax serves as a critical barrier in resisting both biotic and abiotic stresses, its epigenetic regulation during cold stress remains poorly understood.. Here, we show that exogenous arginine alleviates cold‐induced damage by increasing cuticle thickness, and enhancing the accumulation of very‐long‐chain fatty acids and alkanes. Article Title: Schiff-base cross-linked pullulan-chondroitin sulfate hydrogel incorporating raloxifene-poly(2-methyl-2-oxazoline) micelles for localized therapy of postmenopausal osteoarthritis. Article Snippet: Postmenopausal osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage erosion and subchondral bone loss, intensified by estrogen deficiency in menopausal women.. Raloxifene (RLX), a selective estrogen receptor modulator, shows anti-inflammatory and chondroprotective potential but is associated with limited oral bioavailability (~2%) and systemic side effects.. Therefore, in the present investigation, raloxifene-conjugated poly(2methyl-2-oxazoline) micelles hybridized self-cross-linking hydrogel (R-PMeOZ@SCH) was engineered for intra-articular therapy. Article Title: Lactobacillus gasseri suppresses methionine-driven epigenetic programming of trained immunity-like priming to attenuate metabolic dysfunction. Article Snippet: Trained immunity-like epigenetic priming contributes to persistent metabolic inflammation in type 2 diabetes mellitus (T2DM), but the upstream metabolic and microbiota-dependent regulatory mechanisms remain unclear.. Here, we performed an exploratory study to examine whether Lactobacillus gasseri (Lact.. gasseri) attenuates metabolic dysfunction by suppressing methionine-dependent epigenetic priming of innate immune cells, and to characterize how metformin regulates Lact. Article Title: Chrysin as a multi-target regulator of tramadol-induced testicular damage: Integration of inflammation, mitochondrial dynamics, and germ cell survival pathways. Article Snippet: Tramadol, although commonly utilized as an analgesic, is an opioid derivative that may induce significant adverse consequences on the reproductive system.. This study experimentally assessed the toxic effects of tramadol on testicular tissue and reproductive capabilities, as well as the protective capability of chrysin (CHR) against these effects.. The results indicated that tramadol treatment caused considerable functional impairment in testicular tissue, as reflected by a notable reduction in sperm count, motility, and morphology, an elevation in the Cosentino score, and a decline in the Johnsen score and germinal epithelial thickness. Article Title: Conservative Spruce Outperforms Acquisitive Larch Under Warming and CO 2 Article Snippet: These anatomical traits were measured on the transverse section using a |